Alarmin-induced cell migration
نویسندگان
چکیده
منابع مشابه
Interaction of heparin-binding alarmin HMGB1 with human mast cell
HMGB1 (amphoterin) is a 30-kDa transcription factor that is released and secreted to extracellular compartment where its functions as proinflammatory cytokine like alarmin capable to mediate organ damage and lethality. HMGB1 has ability to complex with heparin, LPS, IL-1beta, and DNA that might contribute to its alarmin function. High concentrations of HMGB1 have been detected in serum samples ...
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Background: In avian species, the germ line stem cell population arises outside of the embryonic gonad and proceeds on a circuitous migration to the germinal epithelium. Specifically, in the avian embryo, the process of germ line stem cell migration proceeds through a series of active and passive migratory phases. The germline stem cells or primordial germ cells (PGCs) located in the epiblast o...
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In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...
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Introduction During evolution, multicellular organisms have developed mechanisms to counteract life-threatening events, such as infections and tissue injury, as well as to restore tissue homeostasis. These mechanisms are called ‘the inflammatory response’. To initiate an appropriate inflammatory response, organisms have developed ways to recognize potentially life-threatening events. Danger sig...
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Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins-including the defensins, LL-37, and HMGB1-in tumor dev...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2013
ISSN: 0014-2980
DOI: 10.1002/eji.201243138